«Фараби Әлемі» атты студенттер мен жас ғалымдардың халықаралық конференциясы

SEMIORGANIC TRYPTOPHAN-IODINE COMPLEX AND ITS

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SEMIORGANIC TRYPTOPHAN-IODINE COMPLEX AND ITS
STRUCTURE

Amanzholkyzy A.
Scientific supervisor: Abilov Zh. A.
Al-Farabi Kazakh National University
arai13_95@list.ru

In the case of the problem of antibiotic resistance in pathogenic microorganisms,
the World Health Organization (WHO) urges the government of WHO member
countries and scientists all over the world to intensify the search for new effective drugs
that can withstand the spread of drug resistant microorganisms and the diseases caused
by them.
In a number of promising compounds for the control of drug-resistant pathogens,
the semiorganic iodine coordination compounds with biologically active organic ligands
and alkali metal halides are among the most perspective. Halogens have played an
important role in the development of pharmaceuticals for several decades. The
effectiveness of many complex molecules is significantly enhanced by the presence
of halogen atoms. The majority of halogenated drugs contain fluorine, followed by
chlorine, while those with bromine are rare. Only a few iodine-containing drugs are
known, such as the thyroid hormone thyroxine, an anti-herpesvirus, the antiviral drug
idoxuridine, and amiodaron, a class III antiarrhythmic agent.
For a purposeful search for new iodine coordination compounds with biologically
active ligands, it is necessary to study the influence of the ligand nature and structure of
coordination compounds on pathogenic microorganisms at the molecular level, and to
associate the structure with antimicrobial effectiveness.
It is necessary to find out the mechanism of action of biologically active
compounds on pathogenic microorganisms at the molecular level. This formulation of
the problem emphasizes the importance of knowledge of atomic structures of
compounds. Of all the modern physicochemical methods for studying the atomic
structure of molecules, X-ray diffraction analysis (XRD) is the most reliable technique.
The purpose of these studies was to determine and refine the crystal structure of
the new coordination compound formed in the tryptophan:NaI:iodine system,and unit
cell parameters were determined.A chemical structure of the compound wasdetermined
by X-ray diffraction analysis asC
11
H
12
N
2
O
2
•(C
11
H
13
N
2
O
2
)
+
•Na
+
•2Н
2
О • (I
4
)
2-
. The
coordination compound showed low toxicity and exhibited bactericidal activity against
both susceptible and multiresistant strains of bacteria
S. aureus
,
P. aeruginosa
, and
E.
coli
.
As a result semiorganic complex of iodine was synthesized and the crystal
structure was observed
C
11
H
12
N
2
O
2
•(C
11
H
13
N
2
O
2
)
+
•Na
+
•2Н
2
О •(I
4
)
2-
.
It has low cytotoxicity,
direct antiviral effect, broad-spectrum antimicrobial activity against antibiotic-resistant
strains of microorganisms and is therefore promising for further useas an active
antimicrobial substance.

«Фараби Әлемі» атты студенттер мен жас ғалымдардың халықаралық конференциясы
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